The accident took place at Mawmaram village, about 40 km from state capital Shillong, said N. Rajamarthandan, West Khasi Hills district police chief.
"Four people, including a woman, died on the spot, while the driver of the bus and a passenger succumbed to injuries at hospital," Rajamarthandan told IANS by phone.
The bus was ferrying passengers to Nongstoin, the district headquarters of West Khasi Hills from Shillong, he said.